| Predicate |
Object |
| assignee |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_3dded61bd89f99900518597c0958b9a9 |
| classificationCPCAdditional |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07B2200-13 |
| classificationCPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D237-32 |
| classificationIPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D237-32 |
| filingDate |
2017-01-12-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_0c456b758298dcd40d0aa1af8fde5386
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_31e0213f323b93aa1e4e91a4742c2562
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_d01c1028e933e6f79d1c5cbb21da9e0e |
| publicationDate |
2017-07-20-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber |
US-2017204067-A1 |
| titleOfInvention |
Crystalline forms of olaparib and manufacturing processes therefor |
| abstract |
In certain aspects, the invention provides crystalline forms of olaparib (4-[(3-[(4-cyclopropylcarbonyl)piperazin-4-yl]carbonyl)-4-fluorophenyl]methyl(2H)phthalazin-1-one). In related aspects, the invention provides processes for preparing the crystalline forms of olaparib. The processes include: forming a solution comprising crude olaparib and an organic solvent; adding an anti-solvent to the solution to form a slurry comprising a precipitate; isolating the precipitate; and drying the precipitate to obtain a crystalline form I of olaparib or a crystalline form II of olaparib. |
| isCitedBy |
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-10703728-B1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-2020256636-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-10138211-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/TW-I788675-B |
| priorityDate |
2016-01-14-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type |
http://data.epo.org/linked-data/def/patent/Publication |