| Predicate |
Object |
| assignee |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_06c87200cf96acdabeae38cd1101927d |
| classificationCPCAdditional |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12Q2600-156
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12Q2600-112
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12Q2545-113 |
| classificationCPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/G16B40-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12Q1-6869
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12Q1-6886
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/G16B40-30
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/G16B20-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/G16B20-20
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/G16B20-10 |
| classificationIPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/G16B40-30
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/G16B20-20
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/G16B20-10
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12Q1-68 |
| filingDate |
2016-01-12-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_b70f2a26be1329344e80a19e58fdffb9
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_e3b3fe8122ee754726b32e0dc7c402d5
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_1d201b9ad7bb6d97dc3a6d73551c6abb
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_c7a6c0a641956cf1a091662b1073e620 |
| publicationDate |
2016-07-14-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber |
US-2016201142-A1 |
| titleOfInvention |
Using size and number aberrations in plasma dna for detecting cancer |
| abstract |
Analysis of tumor-derived circulating cell-free DNA opens up new possibilities for performing liquid biopsies for solid tumor assessment or cancer screening. However, many aspects of the biological characteristics of tumor-derived cell-free DNA remain unclear. Regarding the size profile of plasma DNA molecules, some studies reported increased integrity of tumor-derived plasma DNA while others reported shorter tumor-derived plasma DNA molecules. We performed an analysis of the size profiles of plasma DNA in patients with cancer using massively parallel sequencing at single base resolution and in a genomewide manner. Tumor-derived plasma DNA molecules were further identified using chromosome arm-level z-score analysis (CAZA). We showed that populations of aberrantly short and long DNA molecules co-existed in the plasma of patients with cancer. The short ones preferentially carried the tumor-associated copy number aberrations. These results show the ability to use plasma DNA as a molecular diagnostic tool. |
| isCitedBy |
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-11211147-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-110100013-A
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-11211144-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-11519019-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-2018081130-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-11062789-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/GB-2596271-A
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/EP-3574108-A4
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-2021108654-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-11427874-B1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-11342047-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-10626443-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-2018099418-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-2020192680-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-2021224632-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-2018031808-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-10095831-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-11430541-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-2019210873-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-11435339-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/EP-3788172-A4
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/EP-3784806-A4
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-11072814-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-11475981-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-11459616-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/TW-I803477-B
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-2018085862-A2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-2018119452-A2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-2018137685-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-11479825-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-2021023650-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-10633713-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-11603553-B2 |
| priorityDate |
2015-01-13-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type |
http://data.epo.org/linked-data/def/patent/Publication |