http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-11211144-B2
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_009f7007a3eca9c3c982dd2568c33361 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/G16B40-30 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/G16B20-10 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/G16B30-10 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/G16B40-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/G16B40-20 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/G16B40-20 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/G16B30-10 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/G16B20-10 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/G16B40-30 |
| filingDate | 2021-02-18-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2021-12-28-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_9227358dfe48c6c5c133fb6cd230e728 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_4d21c4d4129a45ce72b48501eb9fabc7 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_2bc0213e52eb18d675e0e2c7fed4e3f2 |
| publicationDate | 2021-12-28-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | US-11211144-B2 |
| titleOfInvention | Methods and systems for refining copy number variation in a liquid biopsy assay |
| abstract | Methods, systems, and software are provided for validating a copy number variation in a test subject. A first dataset is obtained comprising bin-level sequence ratios, segment-level sequence ratios and segment-level measures of dispersion. Bins representing regions of a human reference genome are determined from sequencing cell-free nucleic acids in a liquid biopsy sample and reference samples. Segments encompass subsets of adjacent bins, where segment-level sequence ratios and measures of dispersion are determined using bin-level sequence ratios. A copy number status annotation for a segment is validated by applying the first dataset to a plurality of filters comprising a measure of central tendency bin-level sequence ratio filter, a confidence filter, and a measure of central tendency-plus-deviation bin-level sequence ratio filter. When a filter is fired, the copy number status annotation of the segment is rejected; and when no filter is fired, the copy number status annotation of the segment is validated. |
| isCitedBy | http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-2023064309-A1 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-2022150663-A1 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-11613783-B2 |
| priorityDate | 2020-02-18-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 621.