| Predicate |
Object |
| assignee |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_7f49254d7df51c7138ef2fe4dd69badb |
| classificationCPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/G01N33-5073
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/G01N33-5014
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/G01N33-6848 |
| classificationIPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/G01N33-50 |
| filingDate |
2014-04-21-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_dd6ac6ef096459c29f61afef9d033db2
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_649573877d064d0d405e3422213f0d43
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_5ce8456f600d4cbb32640e734ffbbc64
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_341d52316c068b51f13fbfcb46946e18
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_e048b95bacbf424e54802f355f684b7b |
| publicationDate |
2014-09-18-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber |
US-2014273069-A1 |
| titleOfInvention |
Predicting human developmental toxicity of pharmaceuticals using human stem-like cells and metabolomics |
| abstract |
The invention provides biomarker profiles of metabolites and methods for screening chemical compounds including pharmaceutical agents, lead and candidate drug compounds and other chemicals using human stem-like cells (hSLCs) or lineage-specific cells produced therefrom. The inventive methods are useful for testing toxicity, particularly developmental toxicity and detecting teratogenic effects of such chemical compounds. Specifically, a more predictive developmental toxicity model, based on an in vitro method that utilizes both hSLCs and metabolomics to discover biomarkers of developmental toxicity is disclosed. |
| isCitedBy |
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-11237154-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-10767164-B2 |
| priorityDate |
2010-03-22-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type |
http://data.epo.org/linked-data/def/patent/Publication |