| Predicate |
Object |
| assignee |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_b013312f4d5f2795335ae3389552b3bb
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_8ddb4f0fc5c60e6a573466de0876c65a
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_452edf09f236371e61e3fd22a06ded78
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_122a43c2f77b44ea7214bb51fd303444 |
| classificationCPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07F9-12
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K47-48246
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07F9-65512
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P35-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D305-14
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K5-1016
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07F9-6552
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K47-64 |
| classificationIPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K47-48 |
| filingDate |
2014-02-25-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_20ca92229ae3f1c26ef8efe0fad30963
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_62012fab1a8dca178e45d2edd5539a7d
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_e21d854de748ee5fade226980962fa36 |
| publicationDate |
2014-08-21-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber |
US-2014235550-A1 |
| titleOfInvention |
Antineoplastic Hydrogels, and Enzyme-Instructed Preparations Thereof |
| abstract |
Disclosed is a general methodology to create nanofibers of therapeutic molecules that have a dual role, as both the delivery vehicle and the drug itself. It is shown that with proper molecular design, the integration of enzymatic reaction and self-assembly provides a powerful method to create molecular hydrogels of clinically-used therapeutics without compromising their bioactivities. In addition, the results disclosed herein demonstrate enzyme-instructed self-assembly as a facile strategy for generating the supramolecular hydrogels of molecules that inherently have poor solubility in water. For example, by covalently connecting paclitaxel with a motif that is prone to self-assemble, a hydrogel of paclitaxel can be formed without compromising the activity of the paclitaxel. |
| isCitedBy |
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-11191724-B2 |
| priorityDate |
2009-06-26-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type |
http://data.epo.org/linked-data/def/patent/Publication |