Predicate |
Object |
assignee |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_95619119ebf068c9b8efe34d88eccc13 http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_584711da5c2950e9d6e6e5e67b7d4828 http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_efbd211e8dd496ddf7abf25a01d301cb http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_fb138c98045f39e9b20bded9a3934a09 http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_1ca9910de7e8fbcbf3418fe0b3bf76bd |
classificationCPCAdditional |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12Q2600-156 |
classificationCPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12Q1-6883 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12Q1-6806 |
classificationIPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/G01N37-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/B01J20-281 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N15-09 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/G01N33-53 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07H21-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/G01N30-88 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12Q1-68 |
filingDate |
2012-07-24-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
inventor |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_4166be19384859a77efc16a7c146ba1f http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_58e842e472410c8d698ed4314ccd3a15 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_e4f0ca997ab889f696c278008a2f7f92 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_ba19515c57c9403044b4dc40cfd0b255 |
publicationDate |
2012-11-29-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
publicationNumber |
US-2012302741-A1 |
titleOfInvention |
Non-invasive detection of fetal genetic traits |
abstract |
Blood plasma of pregnant women contains fetal and (generally >90%) maternal circulatory extracellular DNA. Most of said fetal DNA contains ≦500 base pairs, said maternal DNA having a greater size. Separation of circulatory extracellular DNA of <500 base pairs results in separation of fetal from maternal DNA. A fraction of a blood plasma or serum sample of a pregnant woman containing, due to size separation (e.g. by chromatography, density gradient centrifugation or nanotechnological methods), extracellular DNA substantially comprising ≦500 base pairs is useful for non-invasive detection of fetal genetic traits (including the fetal RhD gene in pregnancies at risk for HDN; fetal Y chromosome-specific sequences in pregnancies at risk for X chromosome-linked disorders; chromosomal aberrations; hereditary Mendelian genetic disorders and corresponding genetic markers; and traits decisive for paternity determination) by e.g. PCR, ligand chain reaction or probe hybridization techniques, or nucleic acid arrays. |
isCitedBy |
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-9738931-B2 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-2019243328-A1 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-9580751-B2 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-2021116273-A2 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-2013190483-A1 |
priorityDate |
2003-10-16-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
type |
http://data.epo.org/linked-data/def/patent/Publication |