| abstract |
According to the present invention, a compound represented by formula (I): n n n n n n n n n n wherein Q is: n n n n n n n n n n A is a hydrogen atom, a halogen atom, —ORa or a C 1-4 alkyl group which may be substituted by one or more halogen atoms; E is independently selected from a C 1-6 alkyl group; m is selected from integers from 0 to 3; R 2 and R 3 are independently selected from a C 1-6 alkyl group; X 1 and X 2 are independently selected from O and S; Y is selected from an arylene group and a divalent 5- or 6-membered monocyclic or 8- to 10-membered condensed heterocyclic group, wherein the arylene group and the heterocyclic group may be substituted by 1 to 3 substituents independently selected from E 1 ; E 1 is independently selected from a hydroxyl group, a halogen atom, a C 1-4 alkyl group, a cyano group, a C 1-4 alkoky group, a carbamoyl group, a C 1-4 alkylcarbamoyl group, a di(C 1-4 alkyl)carbamoyl group, an amino group, a C 1-4 alkylamino group, a di(C 1-4 alkylamino group, a sulfamoyl group, a C 1-4 alkylsulfamoyl group and a di(C 1-4 alkyl)sulfamoyl group; Z is —CON(—Ra)—, —CO—, —COO—, —NRa—C(═NH)NRb—, —NRa—C(═N—CN)NRb—, —N(—Ra)COO—, —C(═NH)—, —SO 2 —, —SO 2 N(—Ra)—, —SO 2 NR 1 —, —N(—Ra)CO—, —N(—Ra)CON(—Rb)—, —N(COR 1 )CO—, —N(—Ra)SO 2 —, —N(SO 2 R 1 )SO 2 —, —N(—Ra)— or —N(—Ra)SO 2 N(—Rb)—; R 1 is independently a hydrogen atom, a hydroxyl group, a C 1-6 alkyl group which may be substituted by one or more substituents, a heterocyclic group which may be substituted by one or more substituents, an aryl group which may be substituted by one or more substituents, a C 3-8 cycloalkyl group which may be substituted by one or more substituents or a C 3-8 cycloalkenyl group which may be substituted by one or more substituents, or a salt, prodrug or solvate thereof is provided. Furthermore, a pharmaceutical composition containing the compound, and the like are also provided. |