| abstract |
The present invention provides a novel diarylthiohydantoin derivative with a structure of formula I and applications thereof, wherein X is selected from O or S; R and R are the same or different from each other, each representing a hydrogen atom, C 1-6 alkyl, C 1-6 alkoxy, C 3-8 cycloalkyl, C 3-8 cycloalkenyl, etc.; R 3 represents hydrogen atom, halogen atom, hydroxyl, cyano, nitro, etc.; R 4 and R 5 are the same or different from each other, each representing a hydrogen atom, a halogen atom, -C(=O)-N-(C 1-4 alkyl), -(C 1-4 alkyl)-C(=O )-N-(C 1-4 alkyl) etc.; n is 1, 2, 3 or 4. The invention also relates to the use of such compounds in hyperproliferative diseases. |