| Predicate |
Object |
| assignee |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_8e0daec85fdd4a4c04e22225e70a5cd9 |
| classificationCPCAdditional |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12Q2600-16
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12Q2600-154
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12Q2600-112 |
| classificationCPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N15-1093
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12Q1-6886
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12Q1-6827 |
| classificationIPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12Q1-68 |
| filingDate |
2009-05-26-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_8d9ee8540599e723fee85a02700a3c26
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_ef5eca10352dceaef3021b1fe2a94512
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_7f545704f5a0fd8705d731dff7261213
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_e6bcfe662c527a3db52d01b2940b964f |
| publicationDate |
2010-10-28-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber |
US-2010273151-A1 |
| titleOfInvention |
Genome-wide analysis of palindrome formation and dna methylation |
| abstract |
The present disclosure provides methods for detecting the genome-wide presence of methylated DNA and palindrome formation. The present disclosure also provides methods for specific enrichment of methylated DNA or DNA having a DNA palindrome. These methods have demonstrated that somatic palindromes and methylated DNA occur frequently and are widespread in human cancers. Individual tumor types have a characteristic non-random distribution of palindromes in their genome and a small subset of the palindromic loci are associate with gene amplification. The disclosed method can be used to define the plurality of genomic DNA palindromes and regions having methylated DNA associated with various tumor types and can provide methods for the classification of tumors, and the diagnosis, early detection of cancer as well as the monitoring of disease recurrence and assessment of residual disease. |
| isCitedBy |
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/JP-WO2018043724-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/EP-3508588-A4
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-8841075-B1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/EP-3690063-A2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-2013033333-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/KR-102460747-B1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-2014184684-A3
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-9075063-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-2023172860-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-2011136115-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-2017176630-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/JP-7169192-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-10221458-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/EP-2891720-A4
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-2010120033-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-2017067477-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/JP-2015526096-A
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/KR-20190044651-A
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-2012178634-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-10718010-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-2013237445-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-2016083360-A1 |
| priorityDate |
2004-05-28-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type |
http://data.epo.org/linked-data/def/patent/Publication |