| Predicate |
Object |
| assignee |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_692dc75829481c48c017b52f352e2bad |
| classificationCPCAdditional |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/Y10T428-2984
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/B01D15-166 |
| classificationCPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/B01D15-363
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P35-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K9-1271
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-704 |
| classificationIPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K9-127
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/B01D15-04
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/B32B9-00 |
| filingDate |
2007-07-03-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_112fb3bc5794dec105ab9c89b795922a |
| publicationDate |
2009-09-17-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber |
US-2009232883-A1 |
| titleOfInvention |
Method of separating vesicle, process for producing medicinal preparation, and method of evaluation |
| abstract |
A method of separating vesicles whose membrane has been modified with a hydrophilic polymer (polyethylene glycol, etc.). In the method, vesicles (liposome, etc.) differing in the degree of membrane modification are separated by ion-exchange chromatography using a concentration gradient in which the ionic intensity of an eluent is changed with time. Also provided are: a process for producing vesicles purified so as to have a desired degree of modification with a hydrophilic polymer which comprises utilizing the separation method in the step of purifying vesicles; a method of evaluating a medicinal vesicle preparation containing a drug therein, the method comprising using the separation method; and vesicles in which the membrane has been modified with a hydrophilic polymer and which include no vesicle having a degree of membrane modification less than 0.5 mol %. |
| isCitedBy |
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-11167033-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-112680397-A
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-11123293-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-114778712-A
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-11167032-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-2020170948-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-2022145980-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-2022146083-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/AU-2018319594-B2 |
| priorityDate |
2006-07-03-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type |
http://data.epo.org/linked-data/def/patent/Publication |