Predicate |
Object |
assignee |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_2658d45a8e9c71b9598e2bf83242bab3 |
classificationCPCAdditional |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N2501-415 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N2501-70 |
classificationCPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N5-0606 |
classificationIPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N5-0735 |
filingDate |
2008-03-12-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
inventor |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_03402055b3884597296b8da0d7143c6c http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_52e1e4b9f72875138dff61d346676393 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_5179b690f582b07594f80a8516545ec0 |
publicationDate |
2009-04-30-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
publicationNumber |
US-2009111177-A1 |
titleOfInvention |
Maintenance of Embryonic Stem Cells by the GSK-3 Inhibitor 6-Bromoindirubin-3'-Oxime |
abstract |
The present invention relates to methods for maintaining the undifferentiated state of embryonic stem cells without the use of a feeder layer by activating the Wnt signal transduction pathway or by inhibiting glycogen synthase kinase-3 activity by contacting the cell with, inter alia, 6-bromoindirubin-3′-oxime. The present invention also relates to embryonic stem cell lines and cells derived therefrom that have been isolated and cultured in the absence of a feeder layer. |
isCitedBy |
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-2011004379-A1 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-9193954-B2 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-10767164-B2 |
priorityDate |
2003-12-19-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
type |
http://data.epo.org/linked-data/def/patent/Publication |