| Predicate |
Object |
| assignee |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_53453a9f0b5f6816736727b1130d042b |
| classificationCPCAdditional |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N2310-14
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N2310-315
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N2310-322
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N2310-321
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N2320-11
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N2330-30 |
| classificationCPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N15-1138
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N15-1137
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12Y207-11024
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N15-10
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N15-111
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N15-11
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12Y301-03001 |
| classificationIPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A01H1-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N15-82
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N15-113
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N15-11
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07H21-02 |
| filingDate |
2007-09-19-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_4d64962ec58c17d31b87e12683a18615
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_f026631237de3545bf7b3152e3580541
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_1f8ac3925199ed196ba9aaba5f0e5ffd
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_233b96cc270cef1295782264058c2ab2 |
| publicationDate |
2008-10-02-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber |
US-2008242851-A1 |
| titleOfInvention |
Modified polynucleotides for reducing off-target effects in rna interference |
| abstract |
Methods and compositions for performing RNA interference with decreased off-target effects are provided. The methods and compositions permit effective and efficient applications of RNA interference to applications such as diagnostics and therapeutics through the use of modifications to the siRNA. Uniquely modified siRNAs have been developed that reduce off-target effects incurred in gene-silencing. The modifications comprise 2′-O-alkyl or mismatch modification(s) at specific positions on the sense and/or antisense strands. |
| isCitedBy |
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-2012065243-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-11667915-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-8252755-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-8188060-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-8772262-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-9745574-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-9273314-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-9637743-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-10125366-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-2012122800-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-10479992-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-2009209626-A1 |
| priorityDate |
2003-04-02-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type |
http://data.epo.org/linked-data/def/patent/Publication |