http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-2006293247-A1
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_006a26177d8926137d49e76f3079d3bf |
| classificationCPCAdditional | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K38-00 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P5-16 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K5-0821 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K5-0825 |
| classificationIPCAdditional | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K38-00 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K38-06 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P5-16 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07K5-097 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07K7-06 |
| filingDate | 2006-02-01-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_5b6e7095e5412572b4123675b594e469 |
| publicationDate | 2006-12-28-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | US-2006293247-A1 |
| titleOfInvention | TRH-like peptide derivatives as inhibitors of the TRH-degrading ectoenzyme |
| abstract | Peptide derivatives useful as inhibitors of activity of thyrotropin-releasing hormone-degrading ectoenzyme (TRH-DE) are of formula I a : n nwherein: n R 1 is an optionally substituted 4-, 5- or 6-membered heterocyclic ring having one or more heteroatoms, in which at least one carbon atom of the ring is substituted with O or S; X 1 is —CO— or —CS— or —CH 2 CO— or CH(R 4 ) wherein R 4 is H or optionally substituted alkyl or —COOH or —COOR 11 wherein R 11 is optionally substituted alkyl; X 2 and X 3 (which may be the same or different) are —CO— or —CS—; Z is —CH 2 — or —S—or —O— or —NH—; Q is O or S; R 2 is H or optionally substituted alkyl or an optionally substituted carbocyclic ring; R 3 is H or optionally substituted alkyl or an optionally substituted mono- or polycyclic ring, optionally having one or more heteroatoms in the ring(s) and optionally being a fused ring; or R 2 and R 3 together form an optionally substituted mono- or polycyclic ring optionally having one or more heteroatoms in the ring(s) and optionally being a fused ring; R 5 and R 6 (which may be the same or different) are H, or lower alkyl; R 7 and R 8 (which may be the same or different) are H, or optionally substituted lower alkyl; R 9 and R 10 (which may be the same or different) are H, or optionally substituted alkyl, or an optionally substituted carbocyclic ring; Y is —(CH 2 ) n — where n is 0, 1, 2 or 3 provided that when R 2 and R 3 form part of the ring n is 0; and pharmaceutically acceptable salts thereof. |
| priorityDate | 2000-02-17-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
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