| Predicate |
Object |
| assignee |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_90801cea1d1d4514678af2499ab96a6f |
| classificationCPCAdditional |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N2501-335
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K35-12 |
| classificationCPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N5-0676
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N5-0678 |
| classificationIPCAdditional |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K35-12 |
| classificationIPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N5-071
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N5-074
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K35-39 |
| filingDate |
2005-10-20-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_b6498acb7d46907e6d5fa1d637f91721 |
| publicationDate |
2006-05-04-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber |
US-2006093586-A1 |
| titleOfInvention |
Generation and differentiation of adult stem cell lines |
| abstract |
The present invention teaches a new method of stem cell generation involving the establishment of a mesenchymal cell culture, induction of epithelial marker expression and isolation and cloning of the cells expressing epithelial markers and expansion of these cell lines. Further processes are described for a two-step method to induce the differentiation of terminally differentiated cell types such as insulin-producing beta cells of the human pancreas gland. The invention indicates that mesenchymal to epithelial transition may be an important component in the development, renewal and regeneration of animal organ systems and provides a reliable method for in-vitro generation of adult stem cells and terminally differentiated cell types for various uses in medical research and cell therapy of disease. |
| isCitedBy |
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-10767164-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-2011005930-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-2011014161-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-2010166720-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-8633025-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-10093897-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-7807458-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-2006241376-A1 |
| priorityDate |
2004-10-20-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type |
http://data.epo.org/linked-data/def/patent/Publication |