| Predicate |
Object |
| assignee |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_84f4e307c3d530a910727cc7c7ec1daa |
| classificationCPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K16-2896
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K47-6807
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K47-6849 |
| classificationIPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K39-395
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K47-48
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12Q1-68
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07K16-28 |
| filingDate |
2005-05-11-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_6cbe42efc41b60601c92136f1701928b |
| publicationDate |
2005-11-17-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber |
US-2005255120-A1 |
| titleOfInvention |
Composition and method for introduction of DNA directed RNA interference sequences into targeted cells and tissues |
| abstract |
Double-stranded DNA which encodes for a promoter region and for small interfering RNA nucleotide sequences is introduced into specific cells and tissues for the purpose of inhibiting gene expression and protein production in those cells and tissues. Intracellular introduction of the small interfering RNA nucleotide sequences is accomplished by the internalization of a target cell specific ligand bonded to the double-stranded DNA which encodes for a promoter region and for a small interfering RNA nucleotide sequence. The ligand is spontaneously internalized after binding to the cell surface antigen. Optionally, internalization is also facilitated by the binding of a DNA binding protein to the double-stranded DNA. If the unique cell surface antigen is not naturally internalized after binding to its ligand, internalization is promoted by the incorporation of an internalization moiety into the structure of the ligand or attachment of such a peptide to the ligand. |
| isCitedBy |
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-2012006083-A3
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-2012006083-A2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-2009187027-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-8013136-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-8470988-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-2005110067-A3
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-9982265-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-7772387-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-2005110067-A2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-2006035254-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-7893224-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-8058448-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-2008193444-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-7723512-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-8063198-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-7829087-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-7674778-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-8431693-B2 |
| priorityDate |
2004-05-12-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type |
http://data.epo.org/linked-data/def/patent/Publication |