| Predicate |
Object |
| classificationCPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/G01N33-57419
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P43-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P35-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/G01N33-5011 |
| classificationIPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/G01N33-574
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/G01N33-50
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P35-00 |
| filingDate |
2003-02-25-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_2b5a27918c4781d0118ec567dbb748ea
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_defb4b13e13264a9e31c6898b4a32f02
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_581ae34cb6cbf6f4db10e92cbea109c4 |
| publicationDate |
2005-07-21-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber |
US-2005158808-A1 |
| titleOfInvention |
Sumo inhibitors |
| abstract |
A method of identifying a compound that inhibits the sumoylation of Tcf-4 by proteins of the PIAS (protein inhibitor of activated STAT) (for example, PIASy, PIAS1, PIAS3 or PIASxα) is described. Also provided are compounds identified by this method; inhibitors for sumoylation of Tcf-4 by the PFAS family proteins and Tcf-4 desumoylation agents; inhibitors of transcriptional activity of Tcf-4 comprising the above-described inhibitors and/or desumoylation agents; preventives and/or remedies for colon cancer comprising the above-described inhibitors and/or desumoylation agents or the transcriptional activity inhibitors; a method of inhibiting the transcriptional activity of Tcf-4 characterized by inhibiting the sumoylation of Tcf-4 by the PIAS family protein and/or desumoylating sumoylated Tcf-4; and a method of preventing and/or treating colon cancer. |
| isCitedBy |
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-2009098430-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-2013317101-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-9283245-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-2011142514-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-2009169955-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-9238654-B2 |
| priorityDate |
2002-03-01-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type |
http://data.epo.org/linked-data/def/patent/Publication |