http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-2005043539-A1
Outgoing Links
| Predicate | Object |
|---|---|
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D417-12 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D417-12 |
| filingDate | 2004-09-10-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_faeb62e37066632bda28d82c796044ba http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_221216c741ab62bd811fbdd2e59c9ca2 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_4a097c3490caadfec68a99da329d1873 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_70dce9d66f8e8ad38a770a4f13ff9a7d |
| publicationDate | 2005-02-24-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | US-2005043539-A1 |
| titleOfInvention | Process for the preparation of 5-[4-[2-[N-methyl-N-(2-pyridyl) amino] ethoxy] phenyl methyl] thiazolidine-2, 4-dione maleate |
| abstract | The present invention discloses a process for the preparation of 5-[4-[2-[N-methyl-N-(2-pyridyl)amino]ethoxy]phenyl methyl]thiazolidine-2,4-dione maleate (VI) comprising the steps of Coupling 2-[N-methyl-N-(2-pyridyl)amino]ethanol (I) and 4-fluorobenzaldehyde (II) in N,N-dimethylformamide, isolating the coupled product 4[2-[N-methyl-N-(2-pyridyl)amino]ethoxy]benzaldehyde (III), converting said isolated benzaldehyde compound (III) to 5-[4-[2-[N-methyl-N-(2-pyridyl)amino]ethoxy]benzylidene]thiazolidine-2,4-dione (IV) and purifying the same, reducing 5-[4-[2-[N-methyl-N-(2-pyridyl)amino]ethoxy]benzylidene]thiazolidine-2,4-dione, by a novel reduction method for making 5-[4-[2-[N-methyl-N-(2-pyridyl)amino]ethoxy]phenyl methyl]thiazolidine-2,4-dione (V). This reduction method involves reacting the compound (IV) with a novel metal legand complex and a reducing agent, purifying the product (V) obtained by a new method reported in the present invention and converting the said thiazolidine-2,4-dione compound (V) into a pharmaceutically acceptable salt. |
| isCitedBy | http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-2010081695-A1 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-11161795-B2 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-7632841-B2 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-2007265313-A1 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-2005014798-A1 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-7435741-B2 |
| priorityDate | 2004-01-28-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 224.