| Predicate |
Object |
| classificationCPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07J1-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-58
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-57
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-56 |
| classificationIPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-56 |
| filingDate |
2003-12-09-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_d6a9bdda03c10740da7129690a71cab5
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_8d823630221869f760405207599e4089
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_279273285cf506e06bf39d5aa6a3d953
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_068ed653ff40f5dee843be5528359d41 |
| publicationDate |
2004-09-02-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber |
US-2004171596-A1 |
| titleOfInvention |
Prodrugs for use as ophthalmic agents |
| abstract |
The subject invention provides a mechanism by which steroidal quinol compounds confer beneficial ophthalmic effects. The subject compounds possess a lipophilic-hydrophilic balance for transcorneal penetration and are readily reduced into parent phenolic A-ring steroid compounds to provide protection or treatment against various ocular symptoms and disorders. The compounds according to the subject invention appear to be highly advantageous as prodrugs to provide protection and/or treatment against ocular disorders. These prodrugs confer lipid solubility optimal for transocorneal penetration and are readily converted to endogenous reducing agents into active phenolic A-ring steroid compounds. To the extent that these prodrugs have reduced feminizing effects and systemic toxicity, they would be expected to be quite advantageous for protecting or treating the eye against ocular disorders such as cataract or glaucoma without undesired (systemic) side effects). |
| isCitedBy |
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-1962678-B
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-2005222232-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-8618086-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-8623918-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-9675539-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-RE43372-E
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-2006135609-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-2007254920-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-8722739-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-9346837-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-8541466-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-8906962-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-9579270-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-8642644-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-2009318542-A1 |
| priorityDate |
2002-04-01-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type |
http://data.epo.org/linked-data/def/patent/Publication |