| Predicate |
Object |
| assignee |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_50a09e48366aa06b1a5cddf4a655fc7b |
| classificationCPCAdditional |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K2317-34 |
| classificationCPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/G01N33-57415
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K16-2869
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/G01N33-743 |
| classificationIPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/G01N33-74
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/G01N33-574
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07K16-28 |
| filingDate |
2002-08-02-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_99dbd963946f85f4657ef191988efe6f
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_c0ea070f346ed80d9bafe5b8d23cbd53
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_04d08d25f4ab81ecd3d8d3ca4a0b12d2 |
| publicationDate |
2003-05-29-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber |
US-2003099641-A1 |
| titleOfInvention |
Monoclonal antibodies specific for phosphorylated estrogen receptor alpha (Ser118) and uses thereof |
| abstract |
The invention provides monoclonal antibodies that bind the estrogen receptor α (ER α) when phosphorylated at serine 118 (Ser118) in the N-terminal domain, but do not bind to ER α when not phosphorylated at this site. Also provided are methods for determining the phosphorylation of ER α in a biological sample, profiling ER α activation in a test tissue, and identifying a compound that modulates phosphorylation of ER α in a test tissue, by using the disclosed monoclonal antibodies. The sample or test tissue may be taken from a subject suspected of having cancer, such as breast cancer. Kits comprising the phospho-ER α (Ser118) monoclonal antibodies of the invention are also provided. |
| isCitedBy |
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-10548905-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-2009269773-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-10308676-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-2015157343-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-11672762-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-10786461-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/JP-2017512981-A
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-10258676-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-11613555-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-2013036201-A1 |
| priorityDate |
2001-08-03-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type |
http://data.epo.org/linked-data/def/patent/Publication |