| abstract |
The present invention provides a method suitable for identifying and producing peptide and peptidomimetic molecules that are capable of producing a recognized phenotypic effect, even in cases where the endogenous peptide is not yet identified and compounds identified thereby. The invention further provides a method for generating related molecules that can be screened to identify a binding agent optimized for therapeutic use and compounds identified thereby. In a preferred embodiment, the invention provides a method for identifying and producing peptide and peptidomimetic molecules that are capable of modulating a phenotypic effect that is produced by the binding of another ligand to the same or a different receptor and compounds identified thereby. |