| abstract |
The present invention relates to 4-aryl triazoles having the formula: n n n wherein R 1 is independently selected from the group consisting of: lower alkyl, lower alkenyl, lower alkynyl, lower heteroalkyl, lower heteroalkenyl, lower heteroalkynyl, heterocycloalkyl, heteroaryl, halo, CN, OR 4 , SR 4 , S(O)R 4 , S(O) 2 R 4 , and NR 4 R 5 ; and Q is has the general formula: n n n said compounds are useful in treating diseases associated with unwanted cytokine activity, inter alia, interleukin-1 (IL-1) and tumor necrosis factor (TNF) from cells. |