http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-2002165196-A1
Outgoing Links
| Predicate | Object |
|---|---|
| classificationCPCAdditional | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N2310-321 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N2310-322 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K38-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N2310-341 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N15-1135 |
| classificationIPCAdditional | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K38-00 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N15-113 |
| filingDate | 2002-05-07-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_0f9a9d1b1876f49499676a9c689f534c |
| publicationDate | 2002-11-07-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | US-2002165196-A1 |
| titleOfInvention | Oligonucleotide inhibitors of cancer cell proliferation |
| abstract | The K-RAS oncogene is a member of the highly conserved RAS gene family, whose protein products are believed to play a significant role in signal transduction and the regulation of cellular proliferation. Mutation-activated K-RAS is found in 30-50% of both advanced and early stage ovarian cancers. The present invention relates to a method for modulating mutation-activated K-RAS expression in ovarian, colon, lung, thyroid, prostate, skin, and hematologic cancer cells by administering an effective amount of an oligonucleotide targeted against a portion of mRNA for human K-RAS. Oligonucleotides are provided that are specifically hybridizable with mRNA encoding mutation-activated human K-RAS. Such oligonucleotides can be used for therapeutics and diagnostics as well as for research purposes. The present invention further encompasses pharmaceutical compositions comprising the antisense oligonucleotides of the invention. |
| isCitedBy | http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-10221413-B2 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-2015259685-A1 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-2010119529-A1 |
| priorityDate | 2001-05-07-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 221.