| Predicate |
Object |
| classificationCPCAdditional |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/B01J2219-00274
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/B01J2219-00657
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/B01J2219-00524
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/B01J2219-00515
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/B01J2219-00722
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/B01J2219-00659
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/B01J2219-00637
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/B01J2219-00626
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/B01J2219-00608
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/B01J2219-00617
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/B01J2219-00612
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/B01J2219-00527 |
| classificationCPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07H21-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12Q1-6837 |
| classificationIPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07H21-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12Q1-68 |
| filingDate |
2001-11-21-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_746b3cc27cc27c74ce94dd6790f63173
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_74a1e5b769cb6a7cb150401427445d1d
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_fd323b7d3c7b539d40cc12147c28fe0b
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_db188fe639d3bbe75d5cf3d7d9d8d287 |
| publicationDate |
2002-09-26-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber |
US-2002137074-A1 |
| titleOfInvention |
Selectivity of nucleic acid diagnostic and microarray technologies by control of interfacial nucleic acid film chemistry |
| abstract |
The invention provides methods for conducting hybridizations having increased selectivity of hybridization using substrates upon which probe nucleic acids are immobilized. The methods of this invention can be used to increase selectivity in nucleic acid diagnostic devices, such as biosensors and microarrays. The invention provides increased selectivity through control of the substrate surface chemistry and in particular, through control of the density of nucleic acids and other oligomers immobilized on a surface. The invention provides improved signal to noise in hybridization assays via enhanced differences in signal magnitude generated for fully matched target nucleic acid compared to partially matched target nucleic acid prior to signal processing. Specifically, invention provides methods for using substrates having medium-high to high immobilization densities to achieve higher hybridization The methods and substrates of this invention are particularly well-suited to assays for genetic targets in samples that contain genetic species that are very similar in nucleic acid sequence to the genetic target. The methods and substrates of this invention are also well-suite for single nucleotide polymorphism (SNP) analysis. |
| isCitedBy |
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-9436088-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-8691754-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-8691594-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-9637777-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/EP-1595127-A2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-2008058512-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/JP-2007521017-A
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-8415138-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-2006035240-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-8615367-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-10415081-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-7563569-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-2022266125-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-9400259-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-8486629-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-8486720-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-9147037-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-2005042763-A2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-2004158447-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/EP-1595127-A4
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-9709559-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-9251583-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-8795960-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/EP-1692298-A2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/EP-1692298-A4
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-8712123-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-8563247-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-7183050-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-2004171167-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-2003055233-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-2005042763-A3 |
| priorityDate |
2000-11-21-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type |
http://data.epo.org/linked-data/def/patent/Publication |