| Predicate |
Object |
| classificationCPCAdditional |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07B2200-07 |
| classificationCPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07C209-52 |
| classificationIPCAdditional |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C211-29 |
| classificationIPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C209-52 |
| filingDate |
2001-05-11-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_b70031185c27db5f0520103b38949332
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_73be623f51f179e5d37cc29888b36cfa
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_030a88f9a736f9ca15d79213b53df16f
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_e167d791cc1c0729cb178cd01d42ea88
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_4d7e1eb5489089fe5f5f37e2bdfc4508 |
| publicationDate |
2002-08-01-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber |
US-2002103400-A1 |
| titleOfInvention |
Process for producing optically active 1-(fluoro- or trifluoromethyl-substituted phenyl) ethylamine and process for purifying same |
| abstract |
An optically active 1-(fluoro- or trifluoromethyl-substituted phenyl)ethylamine is produced with high optical purity and in an industrially simple and efficient manner by asymmetrically reducing an optically active imine, obtained by dehydration and condensation of a fluoro- or trifluoromethyl-substituted phenylmethyl ketone and an optically active primary amine under acidic conditions, using a hydride reducing agent to convert to an optically active secondary amine, and subjecting the secondary amine or its salt of an inorganic acid or organic acid to hydrogenolysis. In addition, an optically active 1-(fluoro- or trifluoromethyl-substituted phenyl)ethylamine is purified to an even higher optical purity in an industrially simple and efficient manner by converting the optically active secondary amine of the synthetic intermediate obtained by asymmetric reduction, or an optically active 1-(3,5-bis-trifluoromethylphenyl)ethylamine, one of the target compounds, to an inorganic or organic acid salt followed by recrystallization purification. This ethylamine is an important intermediate of pharmaceuticals and agricultural chemicals. |
| isCitedBy |
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-101910101-A
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-2011054223-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-2009275779-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-8212085-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-2004235961-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-2007142670-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-7368609-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-7186865-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-110494553-A
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-7081551-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-2004024253-A1 |
| priorityDate |
2000-05-11-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type |
http://data.epo.org/linked-data/def/patent/Publication |