| Predicate |
Object |
| classificationCPCAdditional |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K2317-622
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K2317-21
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K2317-24
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K38-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K2319-00 |
| classificationCPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K47-68
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K16-241
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K47-6813 |
| classificationIPCAdditional |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K38-00 |
| classificationIPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07K16-24
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K47-48 |
| filingDate |
2000-12-13-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_f83fde929c571c1fc52228110e55adfd
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_d5314bf447afe9a615e1d56b170f4e08 |
| publicationDate |
2001-08-30-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber |
US-2001018507-A1 |
| titleOfInvention |
Tumour necrosis factor binding ligands |
| abstract |
The present invention relates to ligands which bind to human tumor necrosis factor alpha (TNF) in a manner such that upon binding of these ligands to TNF the biological activity of TNF is modified. In preferred forms the ligand binds to TNF in a manner such that the induction of endothelial procoagulant activity of the TNF is inhibited; the binding of TNF to receptors on endothelial cells is inhibited; the induction of fibrin deposition in the tumor and tumor regression activities of the TNF are enhanced; and the cytotoxicity and receptor binding activities of the TNF are unaffected or enhanced on tumor cells. The ligand is preferably an antibody, F(ab) fragment, single domain antibody (dABs) single chain antibody or a serum binding protein. It is preferred, however, that the ligand is a monoclonal antibody or F(ab) fragment thereof. |
| isCitedBy |
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-6887846-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-2005271663-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-11674967-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-11448655-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-11022614-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-2007093651-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-2006286066-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-9321832-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-2004081026-A3
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-10883996-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-2010291103-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-2002137685-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-11174311-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-2009259026-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-8877186-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-10705094-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-2004219643-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-10775385-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-2009155283-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-10969393-B2 |
| priorityDate |
1989-08-07-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type |
http://data.epo.org/linked-data/def/patent/Publication |