http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-10345298-B2
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_87e0796351f86d2a548ba02b85acc233 |
| classificationCPCAdditional | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/G01N2800-285 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/G01N33-564 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/G01N33-564 |
| filingDate | 2015-04-30-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2019-07-09-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_8aec9dd3b9c4519e6b0d445adacc6546 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_82eb32dcec6ca4b28a371e015eccf64f http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_7555f2e3840d44d3d8989fb036a84d4f |
| publicationDate | 2019-07-09-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | US-10345298-B2 |
| titleOfInvention | Diagnosis of multiple sclerosis |
| abstract | The present invention relates to a method for diagnosing multiple sclerosis (MS) and/or clinically isolated syndrome (CIS) and/or radiologically isolated syndrome (RIS) or a predisposition for either condition in a subject, the method comprising determining the presence of an anti-KIR4.1 antibody in a sample obtained from said subject by (a) contacting said sample with a protein; and (b) detecting the formation of a protein-anti-KIR4.1 antibody complex; wherein said protein is KIR4.1, wherein glycosylation of the large extracellular domain of said KIR4.1 is as in human oligodendrocytes or glycosylation of the large extracellular domain is absent; and wherein the formation of said complex is indicative of MS, CIS, RIS or a predisposition therefore. Furthermore provided is an antibody or fragment or derivative thereof competing with the anti-KIR4.1 antibody in a sample obtained from a patient having MS. |
| priorityDate | 2014-04-30-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 36.