http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-10174070-B2
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_ed7b10c8aa12e3f1104614db43c74f8e http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_5670a8f1f070df32157428d3a7ba55be |
| classificationCPCAdditional | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N2501-392 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P43-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P35-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-565 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07J1-0059 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07J41-0044 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N5-0693 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07J1-007 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07J1-0074 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N5-09 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-565 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07J41-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07J1-00 |
| filingDate | 2009-11-30-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2019-01-08-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_cdf12406498de38c1a7c7c247ebaa6b2 |
| publicationDate | 2019-01-08-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | US-10174070-B2 |
| titleOfInvention | 6-substituted estradiol derivatives and methods of use |
| abstract | Disclosed are compounds of the formula: n nwherein R 1 , R 2 , R 3 and R 4 are independently hydrogen, C 1 -C 6 alkyl, halo, a sulfate, a glucuronide, —OH, a bulky group, aryl, cycloalkyl, heteroaryl, heterocycloalkyl, —N(CH 2 ) n ; a phosphate group, and a phosphinate group; R 9 is hydrogen, halogen or alkyl; R 11 is selected from the group consisting of H, C 1 -C 6 alkyl, halogen, a sulfate, a glucoronide, —SO 2 NH 2 , —COOH, —CN, —CH 2 CN—, —NHCN—, —CHO, ═CHOCH 3 , —COO salt, —OSO 2 alkyl, —NH 2 , and —NHCO(CH 2 ) n ; R 12 is selected from the group consisting of H, a C 1 -C 6 alkyl, a sulfate, a glucoronide, a bulky group, aryl, cycloalkyl, heteroaryl and heterocycloalkyl; X is selected from the group consisting of C 1 -C 12 alkyl, C 2 -C 12 alkenyl, C 2 -C 12 alkynyl, halogen, a glucoronide, —NH 2 , —SO 2 NH 2 , —COOH, —CN, —CH 2 CN, —NHCN, —CHO, —COOsalt, —OSO 2 alkyl, —SH, —SCH 3 , —CH[(CH 2 ) n CH 3 ]COOCH 3 , —(CH 2 ) m COOCH 3 , —(CH 2 ) m —O—CH 3 , —(CH 2 ) m —O—(CH 2 ) n CH 3 , (CH 2 ) m —S—CH 3 , —(CH 2 ) m —S—(CH 2 ) n CH 3 , —(CH 2 ) m —NH—(CH 2 ) n CH 3 , —C 2 -C 8 alkenyl-O—(CH 2 ) n CH 3 , —C 2 -C 8 alkenyl-S—(CH 2 ) n CH 3 , —C 2 -C 8 alkenyl-N—(CH 2 ) n CH 3 , —C 2 -C 8 alkynyl-O—(CH 2 ) n CH 3 , —C 2 -C 8 alkynyl-S—(CH 2 ) n CH 3 , —C 2 -C 8 alkynyl-N—(CH 2 ) n CH 3 , —(CH 2 ) m —OH, —(CH 2 ) m —O—NH 2 , —(CH 2 ) m —S—NH 2 , —NH(CH 2 ) m CH 3 , —NH(CH 2 ) m OCH 3 , —NH(CH 2 ) m CHOH—COOH, —N(CH 3 ) 2 , —(CH 2 ) m (NH)CH 2 OH, —NHCOOH, —(CH 2 ) m NHCOOH, —NO 2 , —SCN, —SO 2 alkyl, —B(OH) 2 , —(CH 2 ) m N(CH 3 )—SO 2 —NH 3 , —(CH 2 ) m —NH—SO 2 —NH 2 , —NHC(═S) CH 3 , and —NHNH 2 ; and Y is selected from hydrogen, ═O, —OCO(R 6 ) and —OH; wherein m is an integer between 0-20, n is an integer between 0-8, the symbol represents either a single or a double bond capable of forming a keto group at position 3 or 17; and the symbol represents any type of bond regardless of the stereochemistry; and the respective enantiomers, other stereochemical isomers, hydrates, solvates, tautomers and pharmaceutically acceptable salts of said compounds. The compounds are useful in the treatment of various types of cancer. |
| priorityDate | 2005-09-30-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
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