http://rdf.ncbi.nlm.nih.gov/pubchem/patent/RU-2745626-C1
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_0df35e3fe51c99e418d13cde071076f1 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N15-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P31-14 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N1-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K39-215 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N1-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N15-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P31-14 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K39-215 |
| filingDate | 2020-12-05-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2021-03-29-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_25ee69b0df1e4c358ef0d3894126fe01 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_c4e1043b0156d6f35c5ef1e102326dba http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_116185b7da7884f0add7760a26456476 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_ef4f641d51ddc6476c9f37a2dcd4571b http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_bd36c1911f1e7c2a02ffe55644183ee7 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_8696b74a33cb2df2f252a21448c7c27c |
| publicationDate | 2021-03-29-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | RU-2745626-C1 |
| titleOfInvention | Method of creating a live vaccine against covid-19 based on the probiotic strain enterococcus faecium l3 and a live vaccine enterococcus faecium l3-pentf-covid-19 |
| abstract | FIELD: medicine; virology; microbiology; molecular genetics; biotechnology.SUBSTANCE: invention relates to medicine, virology, microbiology, molecular genetics and biotechnology. Presented is a live vaccine Enterococcus faecium L3-pentF-covid-19, containing a clone of enterococci COVID 19+ with a DNA region SEQ ID No: 1 introduced into its genome, providing expression of a protein having the amino acid sequence SEQID No: 2, stimulating humoral and cellular immunity in against the SARS-CoV-2 virus. Also presented is a method of obtaining the specified vaccine based on the probiotic strain Enterococcus faecium L3, modified as a result of electroporation of the culture of enterococci Enterococcus faecium L3 of the recombinant plasmid DNA pentF-covid-19, SEQ ID No: 1, characterized by the fact that the the pspf region of the plasmid pentF-pspf is replaced by a fragment of the gene of the SARS-CoV-2 spike protein, while the pentF-covid-19 DNA encodes the amino acid sequence SEQ ID No: 2, which functions as the spike protein of the SARS-CoV-2 virus, capable of stimulating humoral and cellular immunity against SARS-CoV-2 virus.EFFECT: oral administration of the Enterococcus faecium pentF-covid-19 vaccine stimulates the development of a specific systemic and local immune response, which is manifested by the production of specific immunoglobulins of classes G and A, as well as increased production of interferon gamma in vaccinated animals.2 cl, 7 dwg, 1 tbl, 5 ex |
| isCitedBy | http://rdf.ncbi.nlm.nih.gov/pubchem/patent/RU-2782529-C1 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/RU-2776484-C1 |
| priorityDate | 2020-12-05-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 70.