http://rdf.ncbi.nlm.nih.gov/pubchem/patent/RU-2737190-C2
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_5df91b83742bcb8697bc96f405f4b8e8 |
| classificationCPCAdditional | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K2300-00 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P31-16 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K45-06 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D519-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-506 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-517 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-519 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-52 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-522 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-5377 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-437 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D471-04 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-517 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-506 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D519-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D471-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-437 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P31-16 |
| filingDate | 2016-12-08-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2020-11-25-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_5795a7033bd280c04ee59cb7c4508eeb http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_f0ae1541da257e401081d01755c2f2bc http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_3b0bf13a045c69a3e9c7faa39478ca15 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_c940a4c77e89ca6f96a0953420358f68 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_1100d584bc0d3324b10914360c2d7904 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_8d0122060d119d5049e5a3951b0c0254 |
| publicationDate | 2020-11-25-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | RU-2737190-C2 |
| titleOfInvention | Influenza virus replication inhibitors, methods of application and using |
| abstract | FIELD: pharmaceuticals. n SUBSTANCE: invention relates to a compound of formula (I), or a stereoisomer thereof, or a pharmaceutically acceptable salt thereof, which have activity on influenza virus RNA polymerase. In formula (I), each R 1 and R 3 independently represents H, F, Cl, Br, C 1-6 alkyl or C 6 aryl and where C 6 aryl is not independently substituted or substituted with one, two, three or four substitutes independently selected from F, Cl or Br; n is equal to 0, 1, 2 or 3; each R 2 independently represents F, C 2-6 alkynyl, OR b , C 3-12 carbocyclyl, C 6 aryl or 5- to 14-membered heteroaryl comprising 1 to 4 heteroatoms independently selected from N, O and S, or two adjacent R 2 together with the atoms to which they are attached form C 5-8 carbocyclic ring, C 6 aromatic ring or 5- to 6-member heteroaromatic ring containing from 1 to 4 heteroatoms independently selected from N, O and S, and where each of C 2-6 alkynyl, C 6 aryl, from 5- to 14-functioned heteroaryl, C 6 aromatic ring and 5- to 6-member heteroaromatic ring is independently not substituted or substituted with one, two, three, four or five R', where R b is C 6 aryl; provided that when m is 1, R 2 is not F and, when m is equal to 2, two of R 2 are not F simultaneously; each R' independently represents F, Cl, Br, CN, NO 2 , OR b , R b O-C 1-4 alkylene, C 1-10 alkyl, C 1-6 haloalkyl, C 3-6 cycloalkyl, C 6 aryl, C 6-10 aryl-C 1-4 alkylene or 6-member heterocyclyl containing 1 to 2 heteroatoms independently selected from N, O and S, where R b represents H, C 1-6 alkyl or C 6 aryl; m is 1 or 2; X has one of subformulas (X-2), (X-3) and (X-5), where R 4 is H; each R 5 and R 6 independently represent H or C 1-6 alkyl; W is C 6-8 mono- or b-carbocyclic system; each V and V' independently represent C 5-8 cycloalkane ring, 5- to 6-member heterocyclic ring containing from 1 to 4 heteroatoms independently selected from N, O and S, or from 5- to 6-member heteroaromatic ring, containing from 1 to 4 heteroatoms independently selected from N and S; each R w independently represents -C(=O)OR b , -NR c R d or C 1-6 alkyl, where each R b , R c and R d independently represents H, C 1-6 alkyl or C 6 aryl; s is 0 or 1; t is equal to 0; p is equal to 1. Invention also relates to a pharmaceutical composition for use in influenza virus RNA polymerase inhibition, containing an effective amount of said compound and optionally further comprising a pharmaceutically acceptable excipient, an adjuvant, a carrier or a combination thereof. n n n n n n EFFECT: there are offered influenza virus replication inhibitors, methods for using them and use. n 18 cl, 3 tbl, 80 ex |
| priorityDate | 2015-12-09-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 836.