| abstract |
1. The compound of formula (I):! ! or its pharmaceutically acceptable salts, where! represents ! or ! R1 is T-R ′ or —Si (R ′) 3; ! R2, R3 and R4 each independently represent halogen, —CN, —NO2 or V — R ′; ! x is 1, 2 or 3; ! each of R5 is independently halogen, —CN, —NO2 or U — R ′, wherein at least one R5 is other than H; ! T, V and U each independently represents a bond or an optionally substituted C1-C6 alkylidene chain in which up to two methylene units of the chain are optionally and independently replaced with the group -NR'-, -S-, -O-, -CS-, - CO2-, -OCO-, -CO-, -COCO-, -CONR'-, -NR'CO-, -NR'CO2-, -SO2NR'-, -NR'SO2-, -CONR'NR'-, -NR'CONR'-, -OCONR'-, -NR'NR'-, -NR'SO2NR'-, -SO-, -SO2-, -PO-, -PO2- or -POR'-; and! each of R ′ represents independently hydrogen or an optionally substituted group selected from a C1-C6 aliphatic group, a 3-8 membered saturated, partially unsaturated or completely unsaturated monocyclic ring having 0-3 heteroatoms selected independently from nitrogen, oxygen or sulfur, or An 8-12 membered saturated, partially unsaturated or completely unsaturated bicyclic ring system having 0-5 heteroatoms selected independently from nitrogen, oxygen or sulfur; or two R 'taken together with the atom (s) to which they are attached, forming an optionally substituted 3-12 membered saturated, partially unsaturated or completely unsaturated monocyclic or bicyclic ring having 0-4 heteroatoms selected independently from nitrogen, oxygen or sulfur, provided that! a) if R1 is substituted cyclopentyl, x is 1, X1 and X3 are CH, then X2 is not a C-R5 group, where R5 is fluoro or OMe; ! b) if R2 and R3 represent H at the same time, and R1 and R4 are independently selected from H or Me, x |