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filingDate 2015-04-22-04:00^^<http://www.w3.org/2001/XMLSchema#date>
grantDate 2018-08-07-04:00^^<http://www.w3.org/2001/XMLSchema#date>
inventor http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_fc6930784e82a1e47e2f94dcef349e0e
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publicationDate 2018-08-07-04:00^^<http://www.w3.org/2001/XMLSchema#date>
publicationNumber RU-2663584-C2
titleOfInvention Method for synthesis of clofarabine
abstract FIELD: medicine; pharmaceuticals. n SUBSTANCE: invention relates to biotechnology and pharmaceutics, in particular to a method for producing clofarabine. 2-chloroadenine is obtained by enzymatic transglycosylation of 2-chloroadenosine and a compound of formula 1, in which R 1 is a purine or pyrimidine base. Partial protection of the hydroxyl groups of 2-chloroadenosine is carried out to obtain a mixture of a compound of formula 4 and a compound of formula 5, in which R 5 independently represents a hydroxyl protecting group. Compound of formula 4 is isomerised to a compound of formula 5. Compound of formula 6 in which OR 6 is a leaving group. Compound of formula 6 is fluorinated to a compound of formula 7 and the compound of formula 7 is deprotected to produce clofarabine. n EFFECT: invention makes it possible to obtain an anticancer nucleoside clofarabine in high yield and without the formation of undesirable α-N9 stereoisomers. n 8 cl, 5 dwg, 5 ex
priorityDate 2014-04-23-04:00^^<http://www.w3.org/2001/XMLSchema#date>
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