Predicate |
Object |
assignee |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_8684c72e6233a867f9b3e9f175186e2a |
classificationCPCAdditional |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/Y02P20-55 |
classificationCPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P35-02 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07H1-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12Y204-02001 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07H19-19 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07H19-16 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07H19-173 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12P19-40 |
classificationIPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07H19-19 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12P19-40 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12P17-18 |
filingDate |
2015-04-22-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
grantDate |
2018-08-07-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
inventor |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_fc6930784e82a1e47e2f94dcef349e0e http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_0699ebf2b6bb210b8cc40df9ff15ce77 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_6fd6590bf28b0c18d226f77dbcdd032d http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_0042e8cd790f761e107c1b50e9447660 |
publicationDate |
2018-08-07-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
publicationNumber |
RU-2663584-C2 |
titleOfInvention |
Method for synthesis of clofarabine |
abstract |
FIELD: medicine; pharmaceuticals. n SUBSTANCE: invention relates to biotechnology and pharmaceutics, in particular to a method for producing clofarabine. 2-chloroadenine is obtained by enzymatic transglycosylation of 2-chloroadenosine and a compound of formula 1, in which R 1 is a purine or pyrimidine base. Partial protection of the hydroxyl groups of 2-chloroadenosine is carried out to obtain a mixture of a compound of formula 4 and a compound of formula 5, in which R 5 independently represents a hydroxyl protecting group. Compound of formula 4 is isomerised to a compound of formula 5. Compound of formula 6 in which OR 6 is a leaving group. Compound of formula 6 is fluorinated to a compound of formula 7 and the compound of formula 7 is deprotected to produce clofarabine. n EFFECT: invention makes it possible to obtain an anticancer nucleoside clofarabine in high yield and without the formation of undesirable α-N9 stereoisomers. n 8 cl, 5 dwg, 5 ex |
priorityDate |
2014-04-23-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
type |
http://data.epo.org/linked-data/def/patent/Publication |