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publicationDate 2017-12-15-04:00^^<http://www.w3.org/2001/XMLSchema#date>
publicationNumber RU-2638785-C1
titleOfInvention Method for prediction of risk of severe preeclampsia development
abstract FIELD: medicine. n SUBSTANCE: method involves isolation of DNA from peripheral venous blood, analysis of MMP-8 (rs1320632) gene polymorphism in combination with other predictors of development of this pregnancy pathology. Risk of severe preeclampsia development is predicted according to the equations of linear discriminant function: y 1 =-14.767+ 2.914x 1 +1.439x 2 +0.222x 3 +14.345x 4 , y 2 =-2.228+2.305x 1 -0.718x 2 +1.888x 3 -0.254x 4 , where x 1 - is genetic version at the MMP-8 (rs1320632) locus (AA - 1; AG or GG - 0), x 2 is presence of preeclampsia in relatives (1 - yes, 0 - no), x 3 is presence of sexually transmitted diseases (1 - yes, 0 - no), x 4 is presence of gynecological pathologies in the anamnesis (1 - yes, 0 - no), in the event that the value of y 1 is greater than y 2 . n EFFECT: effective implementation of therapeutic and preventive measures to prevent pregnancy pathology. n 3 ex, 2 dwg
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