http://rdf.ncbi.nlm.nih.gov/pubchem/patent/RU-2622746-C2
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_5c344e96794242e29c005dcf0b47f0e4 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K39-02 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N1-20 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K39-02 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N1-20 |
| filingDate | 2015-11-09-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2017-06-19-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_d38eb9fd7d34767ad7e1766aff7524a7 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_7b46fd2b9bc3812d00889348fbecff06 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_5dd6cb02d6d96456b315a2eb8780abf4 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_99130665bac3be67dc150abe535127d6 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_943920c8bed64732ba20830e2d0b382c http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_a3b4403970d3d5a2ab98c6470323892c http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_787fe98e4698c5ab0906b5d235c04748 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_1b10c6c6150f812b2cdadefbd178e08a |
| publicationDate | 2017-06-19-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | RU-2622746-C2 |
| titleOfInvention | Method for hyperimmune serum preparation for farm animals necrobacillosis treatment and prevention |
| abstract | FIELD: biotechnology. n SUBSTANCE: method involves hyperimmunization of producer-oxen with a formalin-inactivated antigen isolated from the Fusobacterium necrophorum "0-1" VIEV production strain. The antigen is obtained by cultivation of the Fusobacterium necrophorum "0-1" VIEV production strain. Further, the culture liquid is subjected to ultrafiltration with a pore size of 13-20 kDa, 8-10% of Fusobacterium necrophorum "0-1" VIEV strain bacterial mass is added to the ultrafiltrate to Fusobacterium necrophorum "0-1" VIEV content of 1.5-2.0 billion of cells in 1 cm3, sodium salt of succinate chitosan is added at a final weight concentration of 0.5-1.5%. Inactivation is perfomed using with formalin, taken at a final concentration of 0.3-0.4% for 12-14 days at 37-38°C. Then, the resulting antigen is sorbed on 10-15% aluminium hydroxide in a glycol buffer with pH of 8.4-8.6, taken at a final concentration of 1.8-2.0%. Hyperimmunization of producer-oxen is first carried out with a vaccine to prevent farm animals necrobacteriosis at a dose of 0.4-0.6 ml/animal, then 4-5 weeks later - with the antigen obtained by the method described above at the rate of 1.5-2.0 ml of antigen per 100 kg of animal body weight, at first once, intradermically to the pre-laryngeal inguinal lymph node, together with the oil adjuvant, taken at a weight ratio of 1:0.8-1.0 to the antigen. Then twice with an interval of 5-7 days 0.5-0.6 ml of antigen per 100 kg of animal body weight is injected intradermally, first to the right pre-lobular and left inguinal lymph nodes, then to the left progloidal and right inguinal lymph nodes. n EFFECT: method allows to obtain high quality serum foranimals necrobacillosis prevention and treatment. n 4 ex |
| isCitedBy | http://rdf.ncbi.nlm.nih.gov/pubchem/patent/RU-2701376-C1 |
| priorityDate | 2015-11-09-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 46.