| abstract |
FIELD: chemistry. n SUBSTANCE: invention relates to a compound having a structure of formula n , n where R 1 is alkoxy, OR a , SR a , -S(O)R a , or -S(O) 2 R a ; where R a is alkyl or aryl, optionally substituted with alkyl, haloalkyl, alkoxy and/or halogen; R 2 , R 3 is C 1 -C 6 alkyl; R 4 is hydrogen or C 1 -C 6 alkyl; R 5 is pyridinyl, optionally substituted with a halogen. The invention relates to a pharmaceutical composition containing a pharmaceutically acceptable carrier and a compound of formula I in the concentration which is effective for disrupting Hec1/Nek2 binding in a patient when the composition is administered to the patient. The compounds I are intended for the use when producing a medicinal agent for treating diseases associated with Hec1 dysfunction and/or overexpression, where the compound is present in the medicinal agent in the amount which is effective for disrupting Nek2/Hec1 binding. n EFFECT: compounds intended for disrupting Nek2/Hec1 binding. n 9 cl, 10 dwg, 6 tbl |