| abstract |
FIELD: biotechnologies. n SUBSTANCE: invention refers to synthetic peptide amides of formula I n , which are agonists of a kappa-opiate receptor and show a low inhibition degree P 450 CYP and lower brain penetration degree. Besides, the invention refers to pharmaceutical compositions containing the above compounds. n EFFECT: possibility of using compounds for prophylaxis and curing of pain and inflammation, which are related to different diseases and states. n 17 cl, 9 tbl, 8 dwg, 39 ex |