| abstract |
FIELD: organic chemistry, peptides. SUBSTANCE: invention relates to opioid peptides of the formula (I): X-R 1 -R 2 -R 3 -Q-R 4 -N(Y)Z and its analogues where X is H or C 1-6 -alkyl; Y, Z - H, cyclic aralkyl and C 1-6 -alkyl; R 1 - tyrosyl residue, 2',6'-dimethyltyrosyl residue or their analogue; R 3 , R 4 - aromatic amino acid residue (other values see p. 1 of the invention claim). Peptides show peripheral analgetic effect. EFFECT: valuable pharmacological property of peptides. 21 cl, 1 tbl, 6 dwg, 3 ex |