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classificationIPCInventive http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N1-20
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K35-74
filingDate 2011-09-14-04:00^^<http://www.w3.org/2001/XMLSchema#date>
grantDate 2013-02-20-04:00^^<http://www.w3.org/2001/XMLSchema#date>
inventor http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_296596476d5623dc1f159fcb9ac1bbff
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_6b79868651e21dfc1e70a6e77e620a45
publicationDate 2013-02-20-04:00^^<http://www.w3.org/2001/XMLSchema#date>
publicationNumber RU-2475535-C1
titleOfInvention Method to produce probiotic preparation lacto-amylovorin
abstract FIELD: biotechnologies. n SUBSTANCE: probiotic lacto-amylovorin is produced by means of depth growth of the strain Lactobacillus amylovorus RNCIM B-6253 on the liquid nutrient medium, which contains the following: corn extract - 10 ± 0.01 ml, lactose - 20 ± 0.005 g, chemically deposited chalk - 0.5 ± 0.01 g, triple-substituted citric-acid sodium - 7.5 ± 0.05 g, 3-water acetous sodium - 2 ± 0.01 g, iron sulfate - 0.1± 0.001 g, 5-water manganese sulfate - 0.16 ± 0.002 g, hydrolysate of dry nonfat milk - up to l. Subsequent extraction of the target product in liquid condition or in the form of a dry powder is carried out with preliminary addition of a stabiliser to a cultural liquid or to a protective medium used when producing the probiotic in the form of the dry powder. The stabiliser is selected from: sodium metabisulfite, sodium hydrosulfite and ascorbic acid. n EFFECT: invention provides for stable production of a probiotic with high values of a titre of antimicrobial bodies not only in a cultural liquid, but also after its treatment required for production of different pharmaceutical forms of a preparation. n 3 cl, 2 tbl, 3 ex
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