| abstract |
FIELD: medicine. n SUBSTANCE: invention refers to new 5-substituted derivatives of thiocamptothecin of general formula 1: , wherein: R represents hydrogen, -N3; R1 hydrogen, ethyl, group -CH=N-O-C(CH 3 ) 3 ; R2 represents hydrogen, -CH 2 N(CH 3 ) 2 ; R3 represents hydrogen, hydroxyl, group , to their pharmaceutically acceptable salts, enantiomers, diastereoisomers and related mixtures. n EFFECT: higher anticancer activity of the compound. n 10 cl, 3 tbl, 34 ex |