http://rdf.ncbi.nlm.nih.gov/pubchem/patent/RU-2190613-C2
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_08bed06636bde8962508204df7b867a5 http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_0e6978a9d466aeb9321731deef9295dd |
| classificationCPCAdditional | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/Y02P20-55 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D471-14 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P35-00 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D471-14 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P35-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D491-22 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-47 |
| filingDate | 1997-12-05-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2002-10-10-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_b7bf4c08f543faf63b4d1411c5b0c7e5 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_64538842e18b4cd2831d3e99bfaf499b http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_175072e05a6cd766a1b6f744e5782f35 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_c8382602455543bdc7c5570211094387 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_f3157c2a8f10e44d981168af130f899d http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_6d280ee19676195150c55aa1cc3ad701 |
| publicationDate | 2002-10-10-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | RU-2190613-C2 |
| titleOfInvention | Camptothecin analogs, methods of their synthesis and pharmaceutical composition based on thereof |
| abstract | FIELD: organic chemistry, biochemistry, pharmacy. SUBSTANCE: invention relates to novel analogs of camptothecin of the formula (I) where R 1 means alkyl, alkylene, alkynyl; R 2 , R 3 , R 4 mean H, halogen atom, halogenalkyl, alkyl, alkenyl, -(CH 2 ) m OR 6 , unsubstituted or substituted phenyl or phenylalkyl; or R 3 and R 4 form in common a chain with 3-4 members that can comprise CH, CH 2 , O, N or NR 9 ; R 3 means H, halogen atom, halogenalkyl, alkyl, alkoxy-group, substituted or unsubstituted phenyl or phenylalkyl; R 6 means H; R 9 means H, alkyl; R 18 and R 19 mean H, halogen atom, alkyl, alkoxy-group, hydroxy-group; R 20 means H, halogen atom; R p means H, -C(O)-A-NR 22 R 23 where A means alkylene radical; R 22 and R 23 mean H, alkyl; n = 0-6; if R p means H then R 3 and R 4 in common form a chain with 3 or 4 members. These compounds show an inhibitory activity with respect to monoisomerase (1) and therefore they can be used as an active component in pharmaceutical composition and for its preparing. Also, the invention relates to methods of synthesis of compound of the formula (I) by interaction of compound of the formula (D) with a primary amine and by acylation of compound of the formula (D) or (Ia) with derivatives of C(O)-A-NR 22 R 23 . EFFECT: improved methods of synthesis, valuable biochemical properties. 13 cl, 1 tbl, 26 ex |
| isCitedBy | http://rdf.ncbi.nlm.nih.gov/pubchem/patent/RU-2450008-C2 |
| priorityDate | 1996-12-20-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 185.