| abstract |
FIELD: medicine, pharmaceutics. n SUBSTANCE: present invention refers to an immunodepressant based on a heterocyclic compound of formula n n n n or to its pharmaceutically acceptable salt where X represents a nitrogen atom or CH, both or one of R 1 or R 2 represents a hydrogen atom, hydroxyl, a halogen atom, an amino group, C 1 -C 6 alkoxy or C 1 -C 6 alkyl: R 3 represents a hydrogen atom, difluoromethyl, an amino group, methyl or hydroxymethyl; R 4 or R 5 represents a hydrogen atom or C 1 -C 6 alkyl; R 6 represents morpholino (optionally substituted by one or two C 1 -C 6 alkyl groups), pyrrolidinyl (optionally substituted by hydroxy C 1 -C 6 alkyl), piperidine (which is optionally substituted by an oxygen atom, hydroxyl, formyl or C 1 -C 6 alkyl), piperazinyl (optionally substituted by one or two oxygen atoms, where a nitrogen atom in position 4 is optionally substituted by a substitute selected from a groups consisting of formyl, C 1 -C 6 hydroxyalkyl, C 1 -C 6 alkoxycarbonyl, C 1 -C 6 oxoalkyl, furoyl, benzoyl, methoxybenzoyl, benzylcarbonyl, dimethylcarbamoyl, diethylcarbamoyl, morpholinocarbonyl and methoxyacetyl) or 1,4-diazepano (optionally substituted by one oxygen atom where a nitrogen atom in position 4 is optionally substituted by a substitute selected from a group consisting of formyl, C 1 -C 6 oxoalkyl). Also, the invention refers to a heterocyclic compound of general formula n n n n and to an anticancer drug based on the compound of formula (II). n EFFECT: there are produced new immunodepressant based on the compound of formula (I) and compound of formula (II) which can be used as anticancer drugs. n 12 cl, 8 tbl, 60 ex |