abstract |
FIELD: organic chemistry, pharmacy. SUBSTANCE: invention describes new trisubstituted imidazoles of the general formula (I) where values R 1 ,R 2 ,R 4 are given in p. 1 of the invention claim. Compounds show inhibitory activity with respect to cytokine. Invention describes also a pharmaceutical composition based on compounds of the formula (I), methods of treatment of patients with cytokine-mediated diseases and a method of synthesis of the above indicated compounds. EFFECT: improved method of synthesis and treatment, valuable pharmacological properties. 21 cl |