http://rdf.ncbi.nlm.nih.gov/pubchem/patent/RU-2405766-C2
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_76b6305c90835afa958bb677347f6fbe |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C211-49 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C209-48 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C209-36 |
| filingDate | 2009-01-20-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2010-12-10-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_47e1f4f775318578c2e74de2a7ffe42e http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_d61a0083277ff2c251a22d03ed832d44 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_993f6290318f97405301e80e3b96d613 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_42df0289347f3da2fd1a4924d5f22b8e http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_367deda7927222313508e5b287318231 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_478d39fd3e1163cf2fdb412f159c960d http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_b865d0bf8ae4181a9b9f9d0bb2b61b64 |
| publicationDate | 2010-12-10-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | RU-2405766-C2 |
| titleOfInvention | Method for synthesis of 2-(aminomethyl)-3-phenyl-bicyclo [2,2,1]heptane derivatives |
| abstract | FIELD: chemistry. n SUBSTANCE: invention relates to a method for synthesis of 2-(aminomethyl)-3-phenyl-bicyclo[2.2.1]heptane derivatives of formula , which can be used in medicine as an agent for medicinal preparations having thymoanaleptic, toning effect, involving reaction of acrylonitrile with the corresponding nitrophenyldiazonium chloride and dehydrohalogenation of the product to obtain trans-isomers of cinnamonitrile derivatives which then react with cyclopentadiene,and then reduction of the obtained substituted 3-phenyl-bicyclo[2.2.1]hept-5-ene-2-carbonitriles with hydrogen, where the substituted 3-phenyl-bicyclo[2.2.1]hept-5-ene-2-carbonitriles are reduced by active hydrogen obtained from reacting aluminium, contained in a nickel-aluminium alloy, with potassium hydroxide, while adding aqueous potassium hydroxide solution and powdered nickel-aluminium alloy to the solution of substituted 3-phenyl-bicyclo[2.2.1]hept-5-ene-2-carbonitriles in tetrahydrofuran. n EFFECT: efficient method for synthesis of 2-(aminomethyl)-3-phenyl-bicyclo[2,2,1]heptane derivatives. n 1 cl |
| isCitedBy | http://rdf.ncbi.nlm.nih.gov/pubchem/patent/RU-2495020-C1 |
| priorityDate | 2009-01-20-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 67.