| abstract |
FIELD: organic chemistry, medicine, oncology. n SUBSTANCE: invention relates to new glycosides of indolo[2,3-a]-pyrrolo[3,4-c]carbazol-5,7-diones of the general formula (1) n wherein: -R 1 means residue of mono- or disaccharide in pyranose form taken among the group: D-Rib, L-Ara, D-Xyl, D-Gal, D-Glc, D-Lac; -R 2 means hydrogen atom, methyl group or residue of mono- or disaccharide; -R 3 means hydrogen atom, hydroxyl group, amino-group or formamido-group; each -X 1 and -X 2 means independently of one another hydrogen atom or bromine atom under condition that they can't mean hydrogen atom simultaneously and under condition also that if R 1 means disaccharide residue then R 2 differs from hydrogen atom. Prepared derivatives show, in particular, cytotoxic and antitumor activity against melanoma B16 and Ehrlich tumor. n EFFECT: valuable medicinal properties of derivatives. n 3 cl, 3 tbl, 2 dwg, 8 ex |