abstract |
Among other methods, the administration of an effective amount of a channeled rhodopsin (e.g., Chrimson R), in the form of a protein or nucleic acid, or an effective amount of the channeled rhodopsin fused to a fluorescent protein (e.g., Chrimson R) A method of reactivating a cell is disclosed. The method may include a light stimulus level that induces an RGC response that is less than a radiation safety margin. The method can include delivery by an adeno-associated viral vector. The method may include using a CAG promoter. With this method, an effective amount of channel dorsiflexin (e.g., ChimsonR protein) can be expressed for a long time. |