| abstract |
An antitumor drug having excellent antitumor effect and safety and having an excellent therapeutic effect, comprising an anti-tumor compound represented by the following formula (1) and an anti-HER2 antibody represented by the formula: -L 1 -L 2 -L P -NH- CH 2 ) n 1 -L a - (CH 2 ) n 2 -C (═O) -, wherein the anti-HER2 antibody binds through the linker of L 1 And the antitumor compound provides a link to the carbonyl group at the - (CH 2 ) n 2 -C (= O) - moiety in which the nitrogen atom of the amino group located at position 1 in the antitumor compound serves as the connecting site . (One) |