| abstract |
(57) [Summary] (Modified) [Configuration] The following formula (1) [In the formula, R 1 and R 2 are a hydrogen atom, a hydroxyl group, a halogen atom or the like, R 3 is an alkyl group having 1 to 6 carbon atoms, 4 is a hydrogen atom, an amino group which may have a protective group, Z is an oxygen atom, a sulfur atom, CR 5 R 6 or N R 7 , R 5 and R 6 are a hydrogen atom and an alkyl group having 1 to 6 carbon atoms, R 7 is a hydrogen atom, an alkyl group having 1 to 6 carbon atoms, and m and n are 0, 1 or 2. Hexacyclic camptothecin derivative represented and method for producing the same. [Effect] This compound is excellent in antitumor activity, highly safe, water-soluble, and useful as an antitumor agent. |