Predicate |
Object |
assignee |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_050fc7b82c5d17d9aeb63a7cdcc546b3 |
classificationCPCAdditional |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A01K2227-108 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A01K2217-075 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12Y204-01 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12Y114-99003 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A01K2267-025 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12Y114-18002 |
classificationCPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12Y204-01 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N9-0071 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N9-0083 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A01K67-0276 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N15-8509 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12Y114-99003 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K14-70578 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12Y114-18002 |
classificationIPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N9-02 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07K14-705 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N15-85 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A01K67-027 |
filingDate |
2017-04-28-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
inventor |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_766cf6e5a4cb9426200b055381d7c270 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_0f92059a7273a7997d561d2b8a6ed4b8 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_009d85684634642c8a15bee78b7ae02c http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_ffa9bae53cc6dfdd2b085d4566ef1be7 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_a688990db59d7857e9257bbedb8ef5ce http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_7f16b738d9206cc52fcd5075462ad50d http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_4630bd971cd9e6206750de207ae30aab |
publicationDate |
2018-11-08-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
publicationNumber |
KR-20180121748-A |
titleOfInvention |
Transgenic pigs expressing both shTNFRI-Fc and HA-HO-1 without Gal epitope and N-glycolylneuraminic acid epitope and the Use of thereof |
abstract |
The present invention simultaneously expresses a HO-1 (Heme oxygenase-1) gene and a TNFR1-Fc (Tumor necrosis factor receptor 1-Fc) gene and encodes a GGTA1 (α-1,3-galactosyltransferase) gene and cytidine monophosphate- acetylneuraminic acid hydroxylase gene knock-out, and a method for producing the same. BACKGROUND OF THE INVENTION The transgenic pigs knocking out the human HO-1 and TNFR1-Fc fusion genes of the present invention and knocking out the GGTA1 gene and the CMAH gene are useful for long-term isolation and in vitro culture by the antioxidative and cytoprotective functions of the HO-1 gene The expression of TNFR1-Fc can reduce the inflammatory response mediated by TNF-α mediated by the early transplantation, inhibit the dendritic cell maturation, regulate the proliferation and activation of T cells, Decrease the rejection response and promote early engraftment of the transplanted organ. Furthermore, the survival rate of transplanted organs can be increased by inhibiting GGTA1-induced hyperimmune rejection and acute immune response by CMAH. Thus, the transgenic pig can be used to produce organs whose immune rejection is suppressed when xenotransplantation is performed. |
isCitedBy |
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/KR-102176161-B1 |
priorityDate |
2017-04-28-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
type |
http://data.epo.org/linked-data/def/patent/Publication |