http://rdf.ncbi.nlm.nih.gov/pubchem/patent/KR-20170035450-A
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_6b3e3de86fb3a7d008414342c8035051 |
| classificationCPCAdditional | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N2310-50 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N15-67 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N15-113 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N15-113 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N15-67 |
| filingDate | 2015-09-23-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_0bcfd905a21cfd6e11384d875d808636 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_835114aadf4b7f5bc7d3b3d34362bc26 |
| publicationDate | 2017-03-31-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | KR-20170035450-A |
| titleOfInvention | mRNA nanoparticles and manufacturing method thereof |
| abstract | The present invention relates to nanoparticles for expressing a specific protein by being introduced into cells, and to a method for producing the same. More specifically, the present invention relates to messenger RNA nanoparticles, and to a method for producing the same. Messenger RNA including repeated base sequences for expressing a specific protein is included, and single strand messenger RNA is twisted and tangled, so the expression of a specific protein capable of stimulating the immunity system of cells is promoted. Thus, immunoreactions occur in cells, and various diseases can be treated. Also, plasmid DNA is not transferred, but messenger RNA is transferred, so a nuclear membrane passing step can be skipped after transcription and protein expressing efficiency can be improved. Only messenger RNA which is a biomaterial is included in the nanoparticles of the present invention, so there is no in vivo toxicity and the nanoparticles can be safely used. The nanoparticles are autonomously assembled, and thus have resistance with respect to nuclear acid decomposition. Relatively low plasmid DNA is included, and the nanoparticles are produced through a one-step procedure (RCT). In the procedure, the capping step of a 5 terminal and the polyadenylation of a 3 terminal are skipped. Thus, convenience and economical feasibility can be promoted with respect to the production process. |
| isCitedBy | http://rdf.ncbi.nlm.nih.gov/pubchem/patent/KR-20200089111-A |
| priorityDate | 2015-09-23-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 24.