| abstract |
The present invention relates to the use of glycosylated hemoglobin (HbA1c < RTI ID = 0.0 > (HbA1c < / RTI > ) In the sample. In order to provide reagents that can be used in the above methods and methods having sufficient stability properties of the chemical compounds essential for the reaction, it is proposed to provide the necessary proteolytic cleavage in the form of an inactivated protease, Only reactivate in the reaction system. In a particular embodiment of the invention, for the stabilization of said hemoglobin to spread at a very low pH in the range of 1 to 3, at least one suitable stabilizer must be present in said hemolysis solution and, in relation to the measurement of the amount of HbA1c In embodiments of the present invention where leuco dyes are used, it is proposed in accordance with the present invention to stabilize them with certain phosphine compounds and / or thio compounds. |