| abstract |
The present invention relates to a pharmaceutical composition, an oral preparation, an injectable preparation, and an external preparation and a cosmetic composition for prevention and improvement of atopy, which comprise GPCR19 agonist or sodium taurodeoxycholate and derivatives thereof as an active ingredient Which is superior to conventional steroid ointment and immunosuppressant ointment in the treatment and improvement of atopic dermatitis and directly reduces the amount of serum immunoglobulin IgE which is a main factor of atopic dermatitis, TH1 cytokine which alleviates the dermatitis pathology, reduces TH2 cytokine which exacerbates the pathology of atopic dermatitis, and reduces the infiltration of mast cells, eosinophils and neutrophils in dermal cells, thereby providing a pharmaceutical composition for prevention and treatment of atopy Can be utilized. |